论文部分内容阅读
目的探讨氟作业工人有关生化指标的相关关系。方法选择某铝厂男性电解工及同企业男性机械工各50名进行尿F-、血F-,血清降钙素(CT)、甲状旁腺素(PTH)、碱性磷酸酶(AKP)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)、IgG、IgA、IgM、Cu2+、Zn2+、Ca2+、Mg2+、Se2+水平的测定。结果与对照组相比,暴露组尿F-、血F、CT、PTH、AKP、GSH-Px的差异有显著性(P<0.01);相关分析显示,暴露组尿F-与CAT(r=0.3133,P<0.05)、CT与PTH(r=0.5173,P<0.01)、微量元素Se2+与CAT(r=0.4354,P<0.05)呈正相关,血F-与GSH-Px(r=-0.5202,P<0.01)呈负相关,血中Cu2+、Zn2+、Ca2+、Mg2+间有一定的正相关关系。结论(1)过量氟可影响CT、PTH的分泌;(2)AKP、GSH-Px的改变可作为氟作业工人的健康监护指标;(3)生化指标的相关性研究对探讨工业性氟病机制及早期防治有积极的作用。
Objective To explore the correlation between biochemical indexes and fluorine workers. Methods A total of 50 male electrolytes and male mechanics in an aluminum factory were enrolled in this study. Urinary F-, blood F-, serum calcitonin (CT), parathyroid hormone (PTH), alkaline phosphatase (AKP) The levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), IgG, IgA, IgM, Cu2 +, Zn2 +, Ca2 +, Mg2 + and Se2 + Results Compared with the control group, the differences of urinary F-, CAT, PTH, AKP, GSH-Px in the exposed group were significant (P <0.01) 0.3133, P <0.05). Serum levels of F- and GSH-Px (r = -0.5202, P < P <0.01). There was a positive correlation between Cu2 +, Zn2 +, Ca2 + and Mg2 + in blood. Conclusions (1) Excessive fluoride can affect the secretion of CT and PTH; (2) The changes of AKP and GSH-Px can be used as health monitoring indicators for fluoride-exposed workers; (3) And early prevention and treatment have a positive effect.