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本文利用氯醛糖麻醉猫,在預先靜脉注射利血平1毫克/公斤,六甲基己二銨(C_6)1毫克/公斤,双苄胺10毫克/公斤或二氯异丙基去甲腎上腺素(DCI)5毫克/公斤后20—30分钟,靜脉注射胍乙啶10毫克/公斤或生理盐水1毫升/公斤,以观察在此4药的影响下,胍乙啶对猫的血压、組織儿茶酚胺含量和腎血流动力的作用。 預給利血平与C_6取消胍乙啶第1相降压,双苄胺与DCI則不对抗。說明胍乙啶第1相降压不是由于它作用于β受体的結果,可能是它有弱于C_6的神經节阻断作用。对于胍乙啶的第2相升压作用利血平能够加强,C_6的加强作用較弱,双苄胺則完全抑制胍乙啶的升压,DCI对升压的影响不显著。說明第2相升压是胍乙啶釋放交感神經末梢的去甲腎上腺素,刺激α受体为主的作用。胍乙啶抑制腎上腺釋放腎上腺素,利血平对抗此作用。它的增速腎血流与利尿的作用只是暫时性的。临床上可考虑在靜脉注射胍乙啶前先用双苄胺以防止胍乙啶的升压反应。
In this paper, the use of chloralose anesthesia cats, pre-intravenous injection of reserpine 1 mg / kg, hexamethylhexamethylenediamine (C_6) 1 mg / kg, bisbenzylamine 10 mg / kg or dichloroisopropyl noradrenal (DCI) 5 mg / kg 20-30 minutes, intravenous guanethidine 10 mg / kg or saline 1 ml / kg to observe the effect of the four drugs under the influence of guanethidine on cat blood pressure, tissue Catecholamine content and renal hemodynamic effects. Reserpine precontracted with C_6 cancel guanethidine Phase 1, bisbenzylamine and DCI is not confrontation. It is concluded that the antihypertensive effect of guanethidine phase 1 is not due to its effect on the β receptor. It may be that it has weaker blockage of C_6. For the second phase of guanethidine booster role of reserpine can be strengthened, C_6 enhancement is weak, double benzylamine is completely inhibited guanethidine boost DCI boost effect was not significant. Phase 2 pressure is guanethidine release of sympathetic nerve endings of norepinephrine, stimulating α receptor-based role. Guanidine inhibits the adrenergic release of epinephrine, reserpine against this effect. Its role in increasing renal blood flow and diuresis is only temporary. Clinically, consider the use of bis-benzylamine before intravenous guanethidine to prevent guanidine from increasing.