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目的:对血清线粒体天门冬氨酸氨基转移酶同工酶(m-AST)活性检测酒精性肝病的价值进行分析。方法:将130例酒精性肝病患者作为观察组,另选择130名健康体检者作为参考组,采用免疫抑制法测定两组受检者m-AST水平。结果:观察组患者AST、m-AST活性水平明显高于参考组;经过4周忌酒与积极治疗,观察组AST、m-AST活性和m-AST/AST与治疗前相比差异显著,与参考组无显著差异。结论:通过对酒精性肝病患者m-AST活性水平的监测能够及时发现肝脏疾病改生理病理变化并对预后进行评估,临床应用价值显著。
Objective: To evaluate the value of serum mitochondrial aspartate aminotransferase isozyme (m-AST) in the detection of alcoholic liver disease. Methods: 130 alcoholic liver disease patients as the observation group, another 130 healthy people as the reference group, immunosuppression was used to measure the level of m-AST in both groups. Results: The levels of AST and m-AST in the observation group were significantly higher than those in the reference group. After 4 weeks’ bogey and active treatment, the activity of AST, m-AST and m-AST / AST in the observation group were significantly different from those before treatment No significant difference between groups. Conclusion: The monitoring of m-AST activity in patients with alcoholic liver disease can detect the pathological changes of liver disease in time and evaluate the prognosis. The clinical value is significant.