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目的:观察小青龙汤加味对变应性鼻炎(AR)大鼠鼻黏膜病理形态和血浆组胺含量的影响,揭示小青龙汤加味治疗AR的部分现代生物学基础。方法:将40只W istar雄性大鼠按体重随机分成生理盐水对照组、变应性鼻炎模型对照组、小青龙汤治疗组、小青龙汤加味治疗组、息斯敏治疗组,每组8只。采用卵蛋白全身致敏与局部攻击方法制作AR大鼠模型,光镜观察小青龙汤加味治疗后鼻黏膜病理形态和测定血浆组胺含量,结果进行统计学分析。结果:模型对照组可见鼻黏膜水肿、充血,重度炎细胞浸润,黏膜上皮坏死。各治疗组炎症程度均有改善,以小青龙加味组效果最好。模型组血浆组胺含量明显升高,小青龙汤加味治疗组血浆组胺含量明显降低。小青龙汤加味治疗组优于小青龙汤治疗组。结论:小青龙汤加味治疗AR的作用途径之一是通过降低组胺含量,从而减轻鼻黏膜变应性炎症。
Objective: To observe the effect of Xiaoqinglong Decoction on the pathological morphology and plasma histamine content in nasal mucosa of rats with allergic rhinitis (AR), and to reveal the modern biological basis of Xiaoqinglong Decoction in the treatment of AR. METHODS: Forty Wistar male rats were randomly divided into normal saline control group, allergic rhinitis model control group, Xiaoqinglong Decoction treatment group, Xiaoqinglong Decoction treatment group and Xismin treatment group. Each group contained 8 rats. . Rat AR model was established by whole body sensitization of ovalbumin and local challenge. The pathological morphology of Nasal mucosa and histamine content were determined by light microscopy after Xiaoqinglong Decoction treatment. The results were statistically analyzed. Results: The model control group showed nasal mucosal edema, hyperemia, severe inflammatory cell infiltration, and mucosal epithelial necrosis. The degree of inflammation was improved in each treatment group, and Xiaoqinglong flavored group had the best effect. The plasma histamine content in the model group was significantly increased, and the plasma histamine content in the Xiaoqinglong Decoction-treated group was significantly reduced. Xiaoqinglong Decoction Modified Treatment Group was better than Xiaoqinglong Decoction Treatment Group. Conclusion: One of the ways to treat AR by Xiaoqinglong Decoction is to reduce allergic inflammation of nasal mucosa by reducing histamine content.