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目的探讨血清中白细胞分类、脂联素(APN)、C-反应蛋白(CRP)水平与脑梗死患者神经功能评分及临床预后的关系。方法收集本院2015年9月-2016年9月收治的急性脑梗死患者128例,根据患者临床预后分为预后不良组(27例)和预后良好组(101例),采用ELISA法检测患者血清中白细胞分类、APN、CRP水平,采用Logisitic回归分析探讨急性脑梗死患者临床预后的危险因素。结果预后不良组患者血清CRP、CRP/APN水平高于预后良好组,而预后不良组APN水平低于预后良好组;预后不良组患者白细胞计数、中性粒细胞比例、单核细胞比例、中性粒细胞/淋巴细胞比值均高于预后良好组患者;预后不良组患者NIHSS评分高于预后良好组患者,上述差异均有统计学意义(P<0.05)。CRP/APN、中性粒细胞/淋巴细胞比值、NIHSS评分是脑梗死患者死亡的独立危险因素(P<0.05)。结论急性脑梗死患者临床预后不一,血清中白细胞分类、CRP/APN水平与患者炎症反应密切相关。
Objective To investigate the relationship between serum leukocyte classification, adiponectin (APN), C-reactive protein (CRP) and neurological score and clinical prognosis in patients with cerebral infarction. Methods A total of 128 patients with acute cerebral infarction who were admitted to our hospital from September 2015 to September 2016 were enrolled and divided into two groups according to their clinical prognosis: poor prognosis group (n = 27) and good prognosis group (n = 101) Middle white blood cell classification, APN and CRP levels, and Logisitic regression analysis was used to explore the risk factors of clinical prognosis in patients with acute cerebral infarction. Results The serum CRP and CRP / APN levels in patients with poor prognosis were significantly higher than those with good prognosis, but those with poor prognosis were lower than those with poor prognosis. The patients with poor prognosis had higher levels of white blood cell count, neutrophil ratio, monocyte ratio, The ratio of granulocyte / lymphocyte was higher than that of patients with good prognosis. The patients with poor prognosis had higher NIHSS score than those with good prognosis (all P <0.05). CRP / APN, neutrophil / lymphocyte ratio, NIHSS score were independent risk factors of death in patients with cerebral infarction (P <0.05). Conclusions The clinical prognosis of patients with acute cerebral infarction is different. The classification of serum leukocytes and the level of CRP / APN are closely related to the inflammatory response in patients.