目的 研究乙型肝炎病毒表面大蛋白(large surface protein of HBV,LHBs)N-糖基化修饰对内质网应激的影响.方法 将LHBs基因进行单点突变,检测野生型LHBs和突变型LHBs对内质网应激和EAED路径相关蛋白表达的影响.检测LHBs与多种泛素链的结合状态,确定LHBs的糖基化基序.结果 LHBs N-糖基化修饰与内质网应激有关.N15S、N123S、N177S位点突变
AIM To evaluate the usefulness of total colonoscopy(TCS) for patients undergoing gastric endoscopic submucosal dissection(ESD) and to assess risk factors for co
In this paper we propose an L1 /2 regularizer which has a nonconvex penalty.The L 1/2 regularizer is shown to have many promising properties such as unbiasednes