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目的分析抗生素相关性腹泻(antibiotic associated-diarrhea,AAD)的发病机制、临床表现、辅助检查及治疗方法。方法对我院2006年10月至2007年10月收治的73例AAD患者的临床资料进行回顾性分析。结果所有患者均出现腹泻,每日3～20次,以水样便、糊状便为主。单纯腹泻型所占比例最高(69.86%),结肠炎型次之(19.81)。β-内酰胺类药物腹泻发生率最高,占60.15%,喹诺酮类次之,占16.56%。结论使用抗生素中出现的腹泻要考虑到AAD的可能,需进行粪涂片、粪培养等检查,应停用相关的抗生素,尽早处理。
Objective To analyze the pathogenesis, clinical manifestation, auxiliary examination and treatment of antibiotic associated-diarrhea (AAD). Methods The clinical data of 73 AAD patients admitted to our hospital from October 2006 to October 2007 were retrospectively analyzed. Results All patients had diarrhea, 3 to 20 times a day, with watery, paste-based. Diarrhea accounted for the highest proportion (69.86%), followed by colitis (19.81). The highest incidence of β-lactam drugs diarrhea, accounting for 60.15%, followed by quinolones, accounting for 16.56%. Conclusions The use of antibiotics in diarrhea to take into account the possibility of AAD, the need for stool smear, fecal culture and other tests should be discontinued related antibiotics, as soon as possible.