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目的:探讨益气活血汤治疗冠心病心绞痛对心功能的影响以及具体的作用机制研究.方法:冠心病心绞痛患者118例随机分为两组,对照组58例,观察组60例.对照组患者口服单硝酸异山梨酯缓释片40mg,1次/日,阿司匹林片100mg,1次/日,辛伐他汀片40mg,1次/日,急性发作时舌下含服硝酸甘油0.5mg;两组均4周为1疗程,连续治疗3个疗程后评价疗效.观察比较治疗前后2组患者血清CRP含量、血脂指标、心功能指标及临床疗效.结果:治疗后,总有效率观察组为93.3％高于对照组的72.4％ (P＜0.05).治疗后观察组患者心功能各项指标变化程度均较对照组大(P＜0.05).观察组患者血清CRP的水平低于对照组(P＜0.05),TC、TG、HDL-C及LDL-C的水平则显著较对照组变化明显(P＜0.05).结论:益气活血汤治疗冠心病心绞痛的疗效确切,改善心功能,具体作用机制可能与调节炎症因子水平相关,可以在临床上得到广泛应用.“,”Objective:To investigate the effect of using Yiqi Huoxue Decoction in the treatment of angina pectoris of coronary heart disease on cardiac function and mechanism of concrete study.Methods:118 cases of patients with angina pectoris were randomly divided into 2 groups,58 cases in the controlled group,60 cases in the observation group.The controlled group were treated with Isosorbide Mononitrate Sustained Release Tablets 40mg,1/d,Aspirin Tablets,100mg,1/d,Simvastatin Tablets 40mg,1/d,acute attack sublingual nitroglycerin 0.5mg;2 groups were 4 weeks as 1 course of treatment,evaluation of curative effect of continuous treatment after 3 courses of treatment.To observe and compare the 2 groups before and after treatment the serum CRP content of blood.Fat index,cardiac function index and clinical curative effect.Results:After treatment,the total efficiency of the observation group was 93.3％ higher than 72.4％ in the controlled group (P ＜ 0.05).The observation group after treatment in patients with heart function indexes change degree was higher than those in the controlled group (P ＜0.05).Patients in the observation group the serum levels of CRP were lower than the controlled group (P ＜ 0.05),TC,TG,HDL-C and LDL-C levels were significantly changed significantly compared with the controlled group (P ＜ 0.05).Conclusion:The curative effect of Yiqi Huoxue Decoction in the treatment of angina pectoris of coronary heart disease is effective,may improve heart function,specific mechanism and regulation of inflammatory factors.It can be widely used in clinic.