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目的研究Th17细胞和Treg细胞及相关细胞因子在红细胞输注无效患者外周血中的水平变化。方法采用流式细胞术检测36名反复输注红细胞患者(分为无效组和有效组)外周血中Th17及Treg细胞的变化,采用ELISA方法检测血清中IL-6、IL-23、IL-17和TGF-β的浓度。结果输注无效组患者输血后Th17细胞、IL-6、IL-23和IL-17水平较输血前明显升高(P<0.05),Treg细胞和TGF-β水平较输血前明显降低(P<0.05),差异有统计学意义;有效组患者Th17、Treg、IL-6、IL-23、IL-17和TGF-β水平无改变(P>0.05)。结论红细胞输注无效患者的免疫系统处于活跃状态,Th17、Treg、IL-6、IL-23、IL-17和TGF-β水平变化,这些原因可能参与红细胞输注无效免疫发病过程。
Objective To study the changes of peripheral blood levels of Th17 cells, Treg cells and related cytokines in patients with ineffective erythrocyte infusion. Methods The changes of Th17 and Treg cells in peripheral blood of 36 patients with repeated transfusion of erythrocytes (divided into inactive group and effective group) were detected by flow cytometry. The levels of IL-6, IL-23 and IL-17 And TGF-β concentration. Results The levels of Th17 cells, IL-6, IL-23 and IL-17 in transfused patients were significantly higher than those before transfusions (P <0.05), while the levels of Treg cells and TGF-β in transfused patients were significantly lower than those before transfusions (P < 0.05). There was no significant difference in the levels of Th17, Treg, IL-6, IL-23, IL-17 and TGF-β in the effective group (P> 0.05). Conclusion The immune system of patients with ineffective erythrocyte infusion is active, and the levels of Th17, Treg, IL-6, IL-23, IL-17 and TGF-β are changed. These factors may be involved in the pathogenesis of RBC immunosuppression.