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目的：评估标准化粉尘螨滴剂舌下特异性免疫治疗（ SLIT）过程中患者生活质量（ QOL）的变化。方法回顾性分析49例接受粉尘螨滴剂SLIT治疗满1．5～2年且随访资料完整的变应性鼻炎（ AR）患者的资料。采用迷你型鼻结膜炎生活质量调查问卷（MiniRQLQ ）在治疗前、治疗半年、治疗1年和1．5～2年后，评估患者的QOL，并记录药物评分（ TMS）的变化。用SPSS16．0统计软件分析数据。结果活动受限和其他症状这两个维度在治疗半年后与治疗前相比得分无统计学意义（Z值分别为-0．055和-1．607， P＞0．05），经过1年的免疫治疗后，得分开始有所下降，差异有统计学意义（ Z值分别为-3．595和-5．949， P＜0．05）。在治疗1．5～2年时得分进一步下降。其他维度及总均分均在治疗半年后下降（Z值分别为-3．854，-4．732，-2．903，-4．149， P＜0．05），随治疗时间延长，评分进一步下降。结论 AR患者QOL最受影响的方面为鼻部症状（如鼻塞、流鼻水、打喷嚏）和实际问题（反复擤鼻涕或擦、揉鼻眼），SLIT治疗可明显提高患者QOL。“,”Objective To evaluate the quality of life in patients under care of sublingual immunotherapy.Methods Quality of life in 49 patients who were sensitized to house dust mites and treated with Dermatophagoides farinae drops in a duration of 1.5 to 2 years with complete clinical data was retrospectively analyzed.Mini rhinoconjunctivitis quality of life questionnaire( MiniRQLQ) and the total medication score( TMS) were evaluated before and half a year, 1 year and 1.5-2 years after SLIT treatment.Results After SLIT treatment of 1 year, the scores of domains of activity limitations and other symptoms were lower than before(Z=-3.595,-5.949, P<0.05).The other domains and the total scores significantly decreased after SLIT treatment of half a year(Z=-3.854,-4.732,-2.903,-4.149, P<0.05).As time went on, the scores of MiniRQLQ dropped further.Conclusion The nasal symptoms ( sneezing, stuffy blocked nose and runny nose ) and the practical problems( need to rub nose/eyes, need to blow nose repeatedly ) were signifi-cantly affected.SLIT can improve the QOL of patients with allergic rhinitis.