目的：总结自体瓣膜感染性心内膜炎（ NVE）患者的治疗经验，探讨手术时机的选择对患者感染控制、心功能恢复以及远期死亡率的影响。方法对2006年1月至2013年5月入选的80例NVE患者均应用抗生素治疗，并根据手术时机分为早期手术组38例，晚期手术组42例。同时将患者手术前、后感染相关指标，心功能指标以及术后1年、3年及5年的死亡率进行对比分析。结果早期手术组患者感染控制、心功能的恢复较晚期手术组好（P＜0．05），差异有统计学意义，而且术后3年及5年的死亡率两组比较，差异具有统计学意义。结论对于NVE患者除常规应用抗生素治疗外，早期手术组患者的治疗效果及远期生存率均明显优于晚期手术组。“,”Objective To summarize experience in treating patients with native value endocarditis ( NVE) , and discuss the effect of timing of surgery on the infection control , cardiac function recovery and long-term mortality among patients . Methods Eighty NVE cases with antibiotic treatment were recruited between January 2006 and May 2013 .According to the timing of surgery, the subjects were divided into the early surgery group (38 cases) and the late surgery group (42 ca-ses) .The infection-related markers and cardiac function indexes before and after surgery , and 1-year, 3-year and 5-year mortality after surgery were analyzed .Results The infection control and recovery of cardiac function in the early surgery group were better than in the late surgery group (P<0.05).The difference in 3-year and 5-year mortalities between the two groups was significant .Conclusions For NVE patients with routine antibiotics treatment , the surgical effect and long-term survival rate are much better in the early surgery group than in the late surgery group .