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以脱镁叶绿酸-a甲酯为起始原料,通过对E-环、3-位碳碳双键和20-位meso-氢的结构修饰,在二氢卟吩色基上构建和引进不同的官能团,并进一步利用其3-位乙烯基与重氮甲烷的1,3-偶极环加成反应,完成一系列C-3-吡唑啉基取代的叶绿素类二氢卟吩衍生物的合成.同时,讨论了叶绿素衍生物的1,3-偶极环加成反应的的区域选择性与立体选择性.所得新的叶绿素类二氢卟吩衍生物的化学结构均经UV,IR,1H NMR及元素分析得以证实.
Using pheophorbide-a methyl ester as a starting material, we constructed and introduced on the chlorin base through structural modification of E-ring, 3 -position carbon-carbon double bond and 20-meso-hydrogen Different functional groups, and further utilize its 1,3-dipolar cycloaddition reaction of 3-position vinyl and diazomethane to complete a series of C-3-pyrazolinyl-substituted chlorophylline chlorin derivatives The regioselectivity and stereoselectivity of the 1,3-dipolar cycloaddition reaction of chlorophyll derivatives were also discussed.The chemical structures of the new chlorophyllin chlorin derivatives were studied by UV, IR 1H NMR and elemental analysis were confirmed.