妊娠期间母体血清、羊水、脐血中的抑制素A和激活素A主要来源于胎盘。抑制素A、激活素A的合成分泌可能与胎盘功能有关。在一些妊娠相关疾病,如妊娠滋养细胞疾病、流产、异位妊娠、妊娠期高血压疾病、胎儿缺氧和21三体综合征中,抑制素A和激活素A有不同的变化。测定其在血清、羊水中的表达,可能对这些妊娠相关疾病的预防、诊断、预后评估及随访等有临床指导意义。 During pregnancy, maternal serum, amniotic fluid, and inhibin A and activin A in cord blood are mainly derived from the placenta. Inhibin A, activin A synthesis and secretion may be related to placental function. In some pregnancy-related diseases such as gestational trophoblastic disease, miscarriage, ectopic pregnancy, gestational hypertension, fetal hypoxia and trisomy 21, inhibin A and activin A have different changes. Determination of its expression in serum and amniotic fluid may have clinical significance in the prevention, diagnosis, prognosis evaluation and follow-up of these pregnancy-related diseases.