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高分化肠型胃腺癌是一种具有低度核异型性的少见胃癌变异型,内镜下此型胃癌常表现为一种边界不清的病变,伴轻微凹陷或隆起,无明显黏膜颜色改变,这给胃镜医师在胃镜下诊断高分化肠型胃癌带来不少困难。病理诊断高分化肠型胃癌亦非常具有挑战性,特别是活检标本,常常被误诊为反应性肠上皮化生或不确定为恶性肿瘤。显微镜下见肿瘤性腺体显示为微小的结构异常,如分支或吻合的腺体,常形成如字母W、H、Y、X等形状。由于此型胃癌非常少,约占早期胃癌的1.9%,其临床病理特征和生物学行为还没有被很好的确立。
Well-differentiated intestinal type gastric adenocarcinoma is a rare variant of gastric cancer with low-grade nuclear atypia. Endoscopic gastric-type gastric cancer often presents as an unclear borderline with slight depression or bulging, with no obvious change in mucosal color. This gives endoscopy gastroscopy diagnosis of well-differentiated intestinal type gastric cancer has brought many difficulties. Pathological diagnosis of well-differentiated intestinal type gastric cancer is also very challenging, especially biopsy specimens, often misdiagnosed as reactive intestinal metaplasia or not as a malignant tumor. Microscope tumor glands showed tiny structural abnormalities, such as branches or anastomosed glands, often formed, such as the letters W, H, Y, X and other shapes. Because of this type of gastric cancer is very small, accounting for about 1.9% of early gastric cancer, its clinical and pathological features and biological behavior has not been well established.