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应用流式细胞检测技术对胃癌及癌前病变中P53蛋白表达水平进行定量研究，并对样品行DNA倍体检测，以探讨P53蛋白在胃癌癌变过程中的作用。结果表明：正常胃粘膜中P53蛋白表达水平（FI值）与浅表胃炎无统计学差异，肠化及不典型增生时FI值显著高于浅表胃炎及正常粘膜（P＜0．025
Flow cytometry was used to quantitatively study the expression of P53 protein in gastric cancer and precancerous lesions. DNA ploidy was performed on the samples to investigate the role of P53 protein in gastric carcinogenesis. The results showed that the expression of P53 protein in normal gastric mucosa (FI value) was not significantly different from superficial gastritis. The FI value of intestinal metaplasia and atypical hyperplasia was significantly higher than that of superficial gastritis and normal mucosa (P<0.025).