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胰十二指肠切除术已成为治疗壶腹周围癌、胆总管下端癌以及胰头癌的首选手术方式，其中术后胰瘘是常见的严重并发症，选择适合的胰肠吻合方式，是减少术后胰瘘发生的关键。尽管对胰肠吻合技术进行了许多探索和改进，但胰瘘仍无法避免。笔者通过复习文献，对胰肠吻合技术的发展与改进方面做一综述。“,”Pancreaticoduodenectomy has become the first considered surgical method for periampullary cancers and carcinomas of the distal common bile duct and the head of the pancreas, in which, postoperative pancreatic ifstula is a common severe complication, and proper selection of pancreaticojejunostomy is curtail for reducing postoperative pancreatic fistula. Although many explorations and improvements for pancreaticojejunostomy technique have been made, pancreatic ifstula is still unavoidable. hTe authors, based on literature review, address the technical development and improvement in pancreaticojejunostomy.