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目的:观察对比甲氨蝶呤+来氟米特+白芍总甙胶囊(MTX+LEF)与甲氨蝶呤+柳氮磺胺吡啶+羟氯喹(MTX+SSZ+HCQ)治疗类风湿性关节炎的疗效和安全性。方法:选择我院2009年10月到2011年10月收治的200例类风湿性关节炎患者,将其随机分为两组,观察组和对照组,每组100例。观察组患者进行MTX+LEF治疗;对照组患者进行MTX+SSZ+HCQ治疗。观察对比两组在治疗后4周和12周后的疼痛指数、功能障碍指数等等指标。结果:治疗后,两组患者的症状都得到改善;4周后。观察组患者各项指标明显优于对照组,两组之间差异具有统计学意义,P<0.05;治疗12周后,观察组在ESR和RF改善方面与对照组比较,差异具有统计学意义,P<0.05。结论:两种治疗方法都能有效治疗类风湿性关节炎,但MTX+LEF法起效更快。
Objective: To observe the effects of methotrexate + leflunomide combined with MTX + LEF and methotrexate + sulfasalazine plus hydroxychloroquine (MTX + SSZ + HCQ) on rheumatoid arthritis Efficacy and safety. Methods: 200 patients with rheumatoid arthritis who were treated in our hospital from October 2009 to October 2011 were randomly divided into two groups: observation group and control group, with 100 cases in each group. Patients in the observation group were treated with MTX + LEF; patients in the control group were treated with MTX + SSZ + HCQ. The pain index and dysfunction index of the two groups after 4 weeks and 12 weeks of treatment were observed and compared. Results: After treatment, the symptoms of both groups were improved; after 4 weeks. The observation group was significantly better than the control group of indicators, the difference between the two groups was statistically significant, P <0.05; 12 weeks after treatment, the observation group in the ESR and RF improvement compared with the control group, the difference was statistically significant, P <0.05. Conclusion: Both treatments are effective in the treatment of rheumatoid arthritis, but the MTX + LEF method is more effective.