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[目的]探讨人骨髓核分化抗原(MNDA)在骨肉瘤中的表达及临床意义。[方法]采用免疫组化法检测MNDA在20例骨软骨瘤和42例骨肉瘤组织中的表达,并分析MNDA表达程度与年龄、性别、病理类型和复发、转移等因素的关系。[结果]MNDA在骨肉瘤组的阳性表达率(17%)明显低于骨软骨瘤组(80%)(P<0.01)。MN-DA的阳性表达与性别、年龄无关(P>0.05),与骨肉瘤的病理类型及是否有复发转移相关。[结论]MNDA在骨肉瘤中低表达,为干扰素在骨肉瘤中的研究提供了理论依据。
[Objective] To investigate the expression of human bone marrow nuclear antigen (MNDA) in osteosarcoma and its clinical significance. [Method] The immunohistochemical method was used to detect the expression of MNDA in 20 osteochondroma and 42 osteosarcoma tissues. The relationship between the expression of MNDA and age, sex, pathological type, recurrence and metastasis was analyzed. [Results] The positive rate of MNDA in osteosarcoma group (17%) was significantly lower than that in osteochondroma group (80%) (P <0.01). The positive expression of MN-DA was not related to sex and age (P> 0.05), but also to the pathological type of osteosarcoma and whether there was recurrence or metastasis. [Conclusion] The low expression of MNDA in osteosarcoma provides a theoretical basis for the study of interferon in osteosarcoma.