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目的:探讨超敏C反应蛋白(hs-CRP)在稳定性心绞痛患者PCI围手术期中的变化与术后再狭窄的关系。方法:分析78例稳定性心绞痛患者临床资料,分析其在PCI术前、术后即刻、术后24 h、术后72 h及复查冠脉造影前的超敏hs-CRP水平;术后6个月行冠脉造影复查后分为再狭窄组(10例)及无再狭窄组(68例);比较两组hs-CRP水平。结果:再狭窄组与无再狭窄组比较,两组各项临床特征差异无统计学意义;PCI术后所有患者的hsCRP水平与术前相比均有明显升高,而且再狭窄组患者术后72 h hs-CRP水平高于无再狭窄组(9.81±4.76 vs6.64±2.89,P<0.01),术后24 h时再狭窄组hs-CRP水平高于无再狭窄组(3.77±1.52 vs 2.43±1.05,P<0.05)。结论:稳定性心绞痛患者PCI术后24 h、72 h时hs-CRP明显增高时,提示患者可能出现支架内再狭窄。
Objective: To investigate the relationship between the changes of hs-CRP and perioperative restenosis during perioperative period of patients with stable angina pectoris. Methods: The clinical data of 78 patients with stable angina were analyzed. The hs-CRP levels before PCI, immediately after PCI, 24 h after operation, 72 h after operation and before coronary angiography were analyzed. Six patients The coronary angiography was divided into restenosis group (n = 10) and no restenosis group (n = 68). The levels of hs-CRP in the two groups were compared. Results: There was no significant difference in the clinical features between the two groups in the restenosis group and the non-restenosis group. The hsCRP levels in all the patients after PCI were significantly higher than those in the preoperative restenosis group The level of hs-CRP in restenosis group was higher than that in non-restenosis group (9.81 ± 4.76 vs 6.64 ± 2.89, P <0.01) at 24 h after resuscitation (3.77 ± 1.52 vs 2.43 ± 1.05, P <0.05). Conclusion: The hs-CRP increased significantly at 24 h and 72 h after PCI in patients with stable angina, suggesting that patients may have in-stent restenosis.