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以往对多发性硬化(MS)患者的淋巴细胞亚群的研究颇多,而对多形核白细胞(PMNL)功能的了解甚少。作者报告60例MS患者的PMNL的功能,并与正常组进行对照比较。60例中男性33例,年龄24～60岁(平均42岁),女性27例,年龄24～72岁(平均48岁),病程2个月～30年(平均15年)。全部患者均经临床或实验室检查确诊。60例中57例能自由行走,3例长期卧床。40例未服任何药物,12例服用可的松,7例应用硫唑嘌呤,1例可的松与硫唑嘌呤并用。在未服用药物的40例中,10例复发但无重复感染病史。全组中14例于3～8个月后进行了重复研究。选择年龄、性别与之匹配的60例健康志愿者为对照组。PMNL来自外周血,其
There have been many previous studies on lymphocyte subsets in patients with multiple sclerosis (MS), and little is known about the function of polymorphonuclear leukocytes (PMNL). The authors reported the function of PMNL in 60 patients with MS and compared them to the normal group. There were 33 males and 60 females aged 24-60 years (average 42 years old) and 27 females aged 24-72 years (mean 48 years) with duration of 2 months to 30 years (average 15 years). All patients were diagnosed by clinical or laboratory tests. Of the 60 patients, 57 were able to walk freely and 3 were bedridden. 40 patients did not take any medication, 12 patients took cortisone, 7 patients were treated with azathioprine and 1 patient with cortisone and azathioprine. Of the 40 patients who did not take medication, 10 had recurrent but no recurrent infections. Fourteen patients in the whole group were repeated after 3 to 8 months. Sixty healthy volunteers, whose age and gender were matched, were selected as the control group. PMNL from peripheral blood, its