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环氧化酶(COX)是花生四烯酸生成前列腺素的关键酶。通常认为COX-1参与生理过程,COX-2介导病理环节,在炎性反应中表达升高。COX-2是COX的诱导型,不仅在多种恶性肿瘤组织中的过度表达,参与肿瘤的发生和发展,而且也是许多良性病变发生、发展的重要原因。许多研究表明,COX-2与子宫内膜息肉、鼻息肉的发生密切相关,COX-2或其催化产物在子宫内膜息肉、鼻息肉及声带息肉中高度表达。
Cyclooxygenase (COX) is a key enzyme for arachidonic acid to produce prostaglandins. COX-1 is generally considered involved in physiological processes, COX-2-mediated pathological changes, increased expression in the inflammatory response. COX-2 is an inducible type of COX, which is not only overexpressed in many malignant tumors, but also involved in the occurrence and development of tumors. It is also an important reason for the occurrence and development of many benign diseases. Many studies have shown that COX-2 is closely related to the occurrence of endometrial polyps and nasal polyps. COX-2 or its catalytic products are highly expressed in endometrial polyps, nasal polyps and vocal cord polyps.