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目的探讨胃癌组织中脆性组氨酸三联体(FHIT)基因的表达及其临床意义。方法应用免疫组织化学SP法,检测FHIT在53例胃癌组织及14例癌旁组织中的表达。结果胃癌组织FHIT蛋白阳性表达率(49.1%,27/53)显著低于癌旁组织(92.9%,13/14)(P<0.05);高中分化组与低分化组间(54.8%VS40.9%),淋巴结转移组与无淋巴结转移组间(44.7%VS60.0%),Ⅰ+Ⅱ期组与Ⅲ+Ⅳ期组间(57.9%VS44.1%)FHIT蛋白阳性表达率差异均有统计学意义(P均<0.05)。结论 FHIT基因与胃癌的发生、发展有关,对FHIT蛋白的检测可作为判定胃癌发生及转移能力的一项客观指标。
Objective To investigate the expression of FHIT gene in gastric carcinoma and its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of FHIT in 53 cases of gastric carcinoma and 14 cases of adjacent tissues. Results The positive expression rates of FHIT protein in gastric cancer tissues (49.1%, 27/53) were significantly lower than those in adjacent tissues (92.9%, 13/14) (P <0.05) %), The positive expression rate of FHIT protein in lymph node metastasis group and non-lymph node metastasis group (44.7% VS60.0%), I + Ⅱ group and Ⅲ + Ⅳ group (57.9% VS44.1%) were statistically different Significance (P <0.05). Conclusion The FHIT gene is associated with the occurrence and development of gastric cancer. The detection of FHIT protein may be an objective indicator to determine the occurrence and metastasis of gastric cancer.