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EphA2是一个跨膜酪氨酸激酶受体,属于酪氨酸激酶受体(receptor tyrosine kinases,RTKs)超家族成员之一。EphA2通常以相对较低的水平表达在成人各种上皮细胞中,其在介导相应的信息传递过程中起着关键性的作用,调控着许多方面的细胞行为[1]。近来研究显示,EphA2在多种肿瘤组织中
EphA2 is a transmembrane tyrosine kinase receptor and belongs to a member of the superfamily of receptor tyrosine kinases (RTKs). EphA2, which is usually expressed at relatively low levels in a variety of epithelial cells in adults, plays a crucial role in mediating the corresponding message transmission and regulates many aspects of cellular behavior [1]. Recent studies have shown that EphA2 is in a variety of tumor tissues