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口腔鳞状细胞癌(OSCC)是最常见的口腔颌面部恶性肿瘤中,尽管在过去几十年里在OSCC诊断、预防以及治疗方面均取得了很大的进步但是对于OSCC的具体发病机制仍十分清楚、也缺乏有效的可被广泛接受的诊断指标;当前的研究认为在OSCC发生、发展中基因因素主要包括基因改变及表观遗传修饰异常,表观遗传修饰是可遗传、可逆转的生物学行为,主要包括DNA甲基化、非编码RNA、组蛋白修饰等;近来研究发现在OSCC肿瘤的发病过程中,表观遗传修饰的改变尤其是DNA甲基化与microRNA在其中扮演着重要的角色,其与OSCC存在着密切的关系;对于二者关系的探索将有助于我们理解OSCC的发病机制,进一步改善OSCC患者临床诊疗的现状。因此,本文对当前表观遗传修饰在OSCC患者中的研究现况进行了综述。
Oral Squamous Cell Carcinoma (OSCC) is the most common oral and maxillofacial malignancy, and despite the considerable advances made in the diagnosis, prevention and treatment of OSCC in the past few decades, the specific pathogenesis of OSCC remains It is clear that there is no effective and widely accepted diagnostic criteria; the current study suggests that in the occurrence of OSCC, the development of genetic factors mainly include genetic alterations and epigenetic modifications, epigenetic modifications are heritable, reversible organisms Recent studies have found that in the pathogenesis of OSCC tumors, changes in epigenetic modifications, especially DNA methylation and microRNA play an important role Role, which has a close relationship with OSCC; exploration of the relationship between them will help us to understand the pathogenesis of OSCC and further improve the clinical status of OSCC patients. Therefore, the current status of epigenetic modification in OSCC patients is reviewed.