最近,有人提出有无价值合成更多的核苷衍生物作为抗肿瘤药物。同样的问题亦涉及核苷衍生物之作为抗病毒药物。显然,某些核苷衍生物具有良好的抗病毒作用,例如:5-碘-2’-去氧尿核苷,阿糖胞苷,阿糖腺苷,5-三氟甲基-2’-去氧尿核苷,5-乙基-2’-去氧尿核苷和6-氮杂尿核苷。上述核苷类有的已在临床使用,有的正在临床试验。本文仅讨 Recently, it has been proposed that there is no value in the synthesis of more nucleoside derivatives as anti-tumor drugs. The same problem also involves nucleoside derivatives as antiviral drugs. Obviously, some of the nucleoside derivatives have good antiviral activity, for example: 5-iodo-2’-deoxyuridine, cytarabine, vidarabine, 5-trifluoromethyl- Deoxyuridine, 5-Ethyl-2’-deoxyuridine and 6-Azainucleoside. Some of the above nucleosides have been used clinically, and some are in clinical trials. This article only discusses