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目的观察小剂量顺铂,氟脲嘧啶方案同步放射治疗中晚期食管癌近期疗效及副作用。方法初治中晚期食管癌71例随机分为单放组(35例)和放化组(36例)。放疗采用常规分割1.8-2Gy/次,5次/周,总剂量60～70GY,6～7周完成。放疗同步采用顺铂10～12mg/m~2+生理盐水500ml静脉滴入,氟脲嘧300mg/m~2+5%葡萄糖液滴注6～8小时,2次/周,连用四周。28天为一个周期重复2～3个周期。结果单放组与放化组有效率分别71.4%,91.6%,完全缓解率分别为34.3%,52.7%,部分缓解率分别37.1%,38.9%。两组比较差异有统计学意义(P<0.05)。放化组发生急性消化道反应,白细胞下降等高于单放组,多数为1～2级。结论小剂量顺铂,氟脲嘧啶滴注方案联合放疗方案费用低,疗效好,副作用轻微。
Objective To observe the short-term efficacy and side effects of low-dose cisplatin and fluorouracil simultaneous radiation therapy for advanced esophageal cancer. Methods A total of 71 patients with newly diagnosed esophageal cancer were randomly divided into radiotherapy group (35 cases) and radiotherapy group (36 cases). Radiotherapy using conventional segmentation 1.8-2Gy / time, 5 times / week, the total dose of 60 ~ 70GY, 6 to 7 weeks to complete. Radiotherapy synchronization with cisplatin 10 ~ 12mg / m ~ 2 + saline 500ml intravenous infusion of flucytol 300mg / m ~ 2 + 5% glucose infusion 6 to 8 hours, 2 times / week, once every four weeks. 28 days for a cycle repeated 2 to 3 cycles. Results The effective rates of radiotherapy and radiotherapy alone were 71.4% and 91.6%, respectively. The complete remission rates were 34.3% and 52.7%, respectively, and the partial remission rates were 37.1% and 38.9% respectively. The difference between the two groups was statistically significant (P <0.05). Radiotherapy group had acute gastrointestinal reactions, leukopenia and other higher than the single release group, the majority of 1 to 2 levels. Conclusion Low-dose cisplatin and fluorouracil drip regimen combined with radiotherapy have low cost, good curative effect and mild side effects.