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测定了２５例肺癌病人外周血单位细胞（ＰＢＭＣ）白细胞介素上（ＩＬ－１）水平及ＰＢＭＣ对大肠杆菌脂多糖（ＬＰＳ）、二氧化硅（ＳｉＯ２）的反应性，结果表明，肺癌病人ＩＬ－１水平在刺激前后均显著高于正常人（Ｐ＜０．００１～０．０１），且这种差异不受化疗因素的影响。ＰＢＭ细胞对ＬＰＳ、ＳｉＯ２的反应性比正常人稍低，但统计学分析无显著差异。提示肺癌病人ＩＬ－１增高是机体抗肿瘤免疫反应之一，与病人的细胞因子网络状态有关，对肺癌的诊断有一定的临床价值。
The interleukin (IL-1) level in peripheral blood mononuclear cells (PBMC) and the reactivity of PBMC to lipopolysaccharide (LPS) and silicon dioxide (SiO2) in 25 patients with lung cancer were measured. The results showed that lung cancer patient IL The level of -1 was significantly higher than before and after stimulation (P<0.001 to 0.01), and this difference was not affected by chemotherapy. The reactivity of PBM cells to LPS and SiO2 was slightly lower than normal, but there was no significant difference in statistical analysis. It is suggested that the increase of IL-1 in lung cancer patients is one of the body’s anti-tumor immune responses, which is related to the patient’s cytokine network status, and has a certain clinical value in the diagnosis of lung cancer.