例1:女,9岁。以指间关节粗大就诊。患者为第二胎,足月顺产,生后较一般儿童瘦小,5岁时发现指间关节粗大,无其他不适,未患过严重疾病。母健康,妊娠期未患病或服药。家族史无类似疾病。体检:身高116厘米,坐高61厘米,指间距107厘米。毛发稀疏、细脆色黄。鼻尖较大呈泡状。手小,指间关节粗大,其他关节无畸形。心肺及腹部无异常。实验 Example 1: Female, 9 years old. To the interphalangeal joint treatment. Patients for the second child, term full-term, after birth than the average child thin, 5-year-old found that the interphalangeal joint, no other discomfort, not suffering from serious illness. Mother healthy, not sick during pregnancy or medication. Family history has no similar disease. Physical examination: height 116 cm, height 61 cm, means 107 cm spacing. Thin hair, fine brittle yellow. The tip of the nose was larger bubble. Small hands, finger joints thick, no other joints deformity. No abnormal heart and lungs and abdomen. experiment