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目的：研究内源性睾酮对雄性高脂血症大鼠早期动脉粥样硬化形成的影响及其作用机制。方法：雄性Ｗｉｓｔａｒ 大鼠随机均分为正常对照组、高脂对照组、高脂去势组（ 切除双侧睾丸及副睾） 。实验时间１２ 周。结果：高脂去势组与高脂对照组相比，血浆总胆固醇（ＴＣ） 、甘油三酯（ＴＧ） 浓度相差不明显，低密度脂蛋白（ ＨＤＬ） 水平较高，低密度脂蛋白（ＬＤＬ） ＋ 极低密度脂蛋白（ ＶＬＤＬ） 水平较低，血浆脂质过氧化物（ＬＰＯ） 水平较低；高脂去势组肝脏ＴＣ、ＴＧ 含量高于高脂对照组，而主动脉ＴＣ、ＴＧ 含量低于高脂对照组，高脂去势组主动脉内膜粘附的单核细胞数及油红染色阳性泡沫细胞均少于高脂对照组。结论：内源性睾酮促进雄性高脂血症大鼠早期动脉粥样硬化形成
Objective: To study the effect of endogenous testosterone on the early atherosclerosis in male rats with hyperlipidemia and its mechanism. Methods: Male Wistar rats were randomly divided into normal control group, high fat control group and high fat castration group (bilateral testis and epididymis). The experiment time is 12 weeks. Results: Compared with the hyperlipidemic control group, there was no obvious difference in TC and TG levels between the hyperlipidemic group and the hyperlipidemic control group, and the level of low density lipoprotein (HDL) ) + Very low density lipoprotein (VLDL) and low level of plasma lipid peroxides (LPO). The levels of TC and TG in the liver of high-fat castration group were higher than those in high fat control group, The contents of monocytes and oil-red staining positive cells in the aorta in hyperlipidemic group were lower than those in the high fat control group. Conclusion: Endogenous testosterone promotes early atherosclerosis in male rats with