20%甘露醇作为一种渗透性利尿药具有较好的临床疗效,近年来有关甘露醇诱发急性肾脏损害或肾功能衰竭的病例时有报告,已引起了人们的重视。本文收集了1990～1998年我科收入院的乙型脑炎(乙脑)患者315例,其中20例发生了急性肾脏损害,发生率为635%。现就其发生机制及其防治措施作 20% mannitol has good clinical efficacy as an osmotic diuretic. It has been reported in recent years that mannitol causes acute renal damage or renal failure, which has aroused people’s attention. This article collected 315 cases of Japanese encephalitis (JE) in our hospital from 1990 to 1998, of which 20 cases had acute renal damage, the incidence was 635%. Now on its mechanism and preventive measures for