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目的:探究在HIE(新生儿缺血缺氧性脑病)患儿中应用GM-1(单唾液酸四己糖神经节苷脂)联合丹参治疗的临床疗效及治疗对血浆中PAF(血小板活化因子)的影响情况。方法:截取我院2010年3月～2012年10月共60例HIE患儿,按随机数字表分为联合组及单用组,对比两组患者间临床资料差异性。结果:联合组治疗满意率(显著率+有效率)较单用组高20%;治疗后联合组NBNA评分较单用组优秀,治疗10天时血清中PAF、IL-6、TAX2、TNF-α表达水平联合组明显降低。结论:HIE予在综合治疗后予GM-1、丹参联合治疗,可改善症状、减轻临床症状、降低PAF的内环境表达,控制炎症级联反应逐级放大。
Objective: To investigate the clinical efficacy of GM-1 (monosialotetrahexosyl ganglioside) in combination with Salvia miltiorrhiza in HIE (neonatal hypoxic-ischemic encephalopathy) and its effect on plasma PAF (platelet-activating factor ) Of the impact of the situation. Methods: A total of 60 HIE infants from March 2010 to October 2012 in our hospital were collected and divided into the combined group and the single group according to the random number table. The differences of clinical data between the two groups were compared. Results: The satisfaction rate (significant rate + effective rate) in the combination group was 20% higher than that in the single group. After treatment, the NBNA score in the combined group was better than that in the single group. After treatment for 10 days, the levels of PAF, IL-6, TAX2, The level of expression in the combined group was significantly lower. Conclusions: After HIE treatment, GM-1 and Salvia miltiorrhiza combined treatment can improve the symptoms, relieve the clinical symptoms, reduce the expression of PAF, and control the cascade of inflammation.