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药物作用机理是生物学时代药学、化学、生物学和医学共同关心的领域。研究药物与受体的相互作用模式是揭露药物作用机理的重要途径之一。解析药物分子和受体的X-ray共晶结构,借助分子模拟技术和分子图形软件,可以直观地观察药物与受体在分子级别上的相互作用,揭露作用机理,进行新药设计。熟悉与此相关的文献、了解与此相关的进展、搜集生物大分子结构资源库中的受体结构信息、熟练使用计算机模拟软件以及正确分析药物作用模式是药学、化学、生物学和医学相关专业的本科生、研究生,教师和研究人员必备的知识和技能。及时介绍这些知识和技能是生物学时代教学内容改革的重要任务。为了适应生物学时代医学教育和药学教育教学内容改革需求,本文以抗癌药物与拓扑异构酶Ⅰ的相互作用为示范,诠释熟悉相关文献、了解相关进展、搜集生物大分子结构资源库中受体结构信息、熟悉计算机模拟软件以及分析药物作用模式的过程和技巧,展示教学内容改革的魅力。
The mechanism of drug action is a field of common interest in pharmacy, chemistry, biology and medicine in the biological age. Studying drug-receptor interaction model is one of the important ways to reveal the mechanism of drug action. Analyze the X-ray eutectic structure of drug molecules and receptors. With molecular simulation technology and molecular graphic software, we can intuitively observe the interaction between drugs and receptors at the molecular level to reveal the mechanism of action and design new drugs. Familiar with this related literature to understand the progress associated with this, to collect receptor structure information in the biological macromolecular structure resource library, proficient use of computer simulation software and the correct analysis of the mode of action of the drug is a pharmacy, chemistry, biology and medical related professional Undergraduates, graduate students, teachers and researchers essential knowledge and skills. Timely introduction of these knowledge and skills is an important task for the reform of teaching content in the biological era. In order to adapt to the need of reform in medical education and pharmacy education in the biology era, this paper takes the interaction between anticancer drugs and topoisomerase Ⅰ as a model, interprets familiar with the relevant literature and understand the progress, and collects the biological macromolecular structure resource library Body structure information, familiar with the computer simulation software and analysis of the role of the drug mode of operation and skills to demonstrate the charm of teaching reform.