论文部分内容阅读
对10例急性淋巴细胞性白血病（ALL）患儿，在超大剂量程序化疗取得持续完全缓解（CCR）两年以上后，采用大剂量阿糖胞苷（HD－Ara－c）和大剂量甲氨喋呤（HD－M．T．X）间断交替冲击治疗，取得了较好的效果。该方法有效地预防了脑膜和睾丸白血病的发生，克服了肿瘤细胞对抗癌药的耐受性，从而增强了抗癌效果，结果表明无一患儿发生睾丸白血病和脑膜白血病，皆呈持续无病生存状态，最长已无病生存4年以上。
In 10 children with acute lymphoblastic leukemia (ALL), high-dose cytarabine (HD-Ara-c) and high-dose methyl ammonia Alternate intermittent impact therapy with methotrexate (HD-M.T.X) achieved good results. The method effectively prevents the occurrence of meningeal and testicular leukemia and overcomes the tolerance of the tumor cells to anticancer drugs, thereby enhancing the anticancer effect. The results show that none of the children have testicular leukemia and meningoglial leukemia, showing no sustained Disease survival status, the longest disease-free survival of more than 4 years.