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目的分析药物性肝损伤的临床表现以及所致的可疑药物,探讨药物性肝损伤的特点。方法采用回顾性调查方法,对本院2006-2011年间收住院的54例药物性肝损伤病例进行统计分析。结果 54例药物性肝损害病例中可疑药物以抗结核药居首位,占22.2%;解热镇痛药居第2位,为18.5%;中草药居第3位,占16.7%。临床分型:肝细胞型损伤38例,淤胆型肝损伤6例,混合型肝损伤9例。结论药物性肝损伤的可疑药物主要为抗结核药、解热镇痛药、中草药,特点为隐匿发病,及时发现处理大部分可治愈或好转。
Objective To analyze the clinical manifestations of drug-induced liver injury and the suspicious drug caused by it, and to explore the characteristics of drug-induced liver injury. Methods A retrospective survey was conducted to analyze 54 cases of drug-induced liver injury admitted to our hospital from 2006 to 2011. Results Among the 54 cases of drug-induced liver damage, suspicious drugs ranked first with anti-TB drugs, accounting for 22.2%; anti-pyretic and analgesic drugs ranking the second with 18.5%; Chinese herbal medicines ranked 3rd with 16.7%. Clinical classification: hepatocellular damage in 38 cases, cholestatic liver injury in 6 cases, mixed liver injury in 9 cases. Conclusion Drug-induced liver injury suspicious drugs are mainly anti-TB drugs, antipyretic analgesics, Chinese herbal medicine, characterized by occult onset, promptly found that most of the treatment can be cured or improved.