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三相口服避孕片是模拟体内激素变化而设计的,每个周期所用的雌、孕激素总剂量低于固定剂量的复合型口服避孕片(OC),而避孕效果相等。本研究对左旋18甲(LNG)+乙炔雌二醇(EE)的三相OC的临床及代谢效应进行评价。研究包括409例38岁以下(吸烟者34岁以下)要求用OC避孕的健康妇女,参与研究前至少有3个周期月经规则,所有研究对象均无血栓栓塞、脑血管、心血管、肝、肾疾病,乳房或生殖道恶性肿瘤及乳房良性肿瘤、严重精神忧郁、高血压、糖尿病和正在用抗惊厥药物治疗。每周期服三相片21片,即周期第1～6天LNG50μg+EE30μg,第7～11天
Three-phase oral contraceptive tablets are designed to simulate the hormone changes in the body. The total dosage of estrogen and progestin used in each cycle is lower than that of the fixed-dose oral contraceptive tablets (OC), and the contraceptive effect is equal. This study evaluated the clinical and metabolic effects of three-phase OC of LNG + ethinyl estradiol (EE). The study included 409 healthy women under 38 years of age (smokers under 34 years of age) requiring contraception with OC. There were at least 3 cycles of menstrual rule before the study, and none of the subjects were thromboembolic, cerebrovascular, cardiovascular, hepatic, and renal Diseases, breast or genital malignancies and benign breast tumors, severe mental depression, high blood pressure, diabetes and being treated with anticonvulsant medications. Take three photos per cycle 21, that is, the cycle of 1 to 6 days LNG 50μg + EE30μg, the first 7 to 11 days