常规病理诊断工作中常可遇到一些皮肤、粘膜的活检,很难确定为良性鳞状上皮增生、乳头瘤抑或是高度分化的鳞状细胞癌。有时甚至重复多次活检也不能肯定病变性质,以致造成病人痛苦及延迟确诊。除取材不当或组织过少等原因外,往往是由于对一 In routine pathological diagnosis, some skin and mucous membrane biopsies are often encountered. It is difficult to determine whether it is benign squamous epithelial hyperplasia, papilloma or highly differentiated squamous cell carcinoma. Sometimes even repeated biopsy can not confirm the nature of the lesion, resulting in patient suffering and delayed diagnosis. In addition to inappropriate materials or too few organizations, it is often due to