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目的 观察博宁对乳腺癌骨转移的止痛效果。方法 应用博宁加化疗和单用化疗两组对照研究。结果 治疗组30例博宁加化疗止痛效果CR 16例(53.3％),PR11例(36.7％),止痛总有效率CR+PR 27例(90.0％)。对照组28例单用化疗,止痛效果CR 4例(14.3％),PR6例(21.4％),止痛总有效率CR+PR 10例(35.7％)。两组差异显著(P<0.05),博宁应用中除少数出现骨痛加重外,余无异常。结论 博宁是一种安全有效,毒副作用小,作用时间长的新一代双膦酸盐制剂,与化疗并用于乳腺癌骨转移,止痛效果更好。
Objective To observe the pain relief effect of Boning on bone metastasis of breast cancer. Methods Bonning plus chemotherapy and chemotherapy alone two control study. Results In the treatment group, the analgesic effect of Bonin plus chemotherapy was 16 cases (53.3%), PR11 cases (36.7%) and analgesic total effect CR + PR (90.0%). The control group of 28 patients with chemotherapy alone, pain relief CR 4 cases (14.3%), PR 6 cases (21.4%), total pain relief CR + PR 10 cases (35.7%). Significant difference between the two groups (P <0.05), Bonin application in addition to a few cases of increased bone pain, I no exception. Conclusion Bonin is a new generation of bisphosphonate preparation which is safe and effective, has small toxic and side effects and long acting time. It has better analgesic effect than chemotherapy and bone metastasis of breast cancer.