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[目的]研究β_连环蛋白在胃癌及癌旁组织中的表达及其与肿瘤细胞分化、浸润、转移等生物学行为的关系。[方法]应用免疫组织化学ABC法检测75例胃癌及癌旁组织石蜡标本β_连环蛋白的表达水平。[结果]β_连环蛋白在癌组织中的表达明显高于癌旁组织 ,低分化癌组织较高分化、中分化组织β_连环蛋白的表达高 ,有淋巴结转移的组织较无转移的表达高 ,浸润程度越深表达越高。[结论]β_连环蛋白是一个与胃癌发生及发展较为相关的生物学指标 ,可能可以作为观察胃癌细胞侵袭转移的较有价值的病理指标。
[Objective] To investigate the expression of β-catenin in gastric cancer and adjacent non-cancerous tissues and its relationship with the biological behavior of tumor cells such as differentiation, invasion and metastasis. [Method] Immunohistochemical ABC method was used to detect the expression of β-catenin in paraffin-embedded specimens of 75 cases of gastric cancer and its adjacent tissues. [Results] The expression of β-catenin in cancer tissues was significantly higher than that in adjacent non-cancerous tissues. The expression of β-catenin in well differentiated and differentiated cancer tissues was higher than that in non-cancerous tissues, and lymph node metastasis was higher than that in non-metastatic tissues , The deeper the degree of infiltration the higher the expression. [Conclusion] β-catenin is a biological indicator which is more related to the occurrence and development of gastric cancer, which may be used as a valuable pathological indicator for the invasion and metastasis of gastric cancer.