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对小檗碱抗富含血小板血浆凝块收缩的作用进行研究，结果表明①小檗碱（ＢＲ）浓度为０．２９～０．８７ｍｍｏｌ·Ｌ－１时．有非常显著的抑制凝块收缩的作用。②ＢＲ浓度为０．５～２．０ｍｍｏｌ·Ｌ－１时．对血小板ｃＡＭＰ水平无影响．提示ＢＲ抑制凝块收缩的作用与ｃＡＭＰ无关．③当外加Ｃａ２＋浓度自０增加到１１．４７ｍｍｏｌ·Ｌ时，凝块收缩率随Ｃａ２＋内流增加而上升。同样条件下．ＢＲ浓度自０增加到０．６ｍｍｏｌ·Ｌ－１时．凝块收缩率显著或非常显著地下降。提示ＢＲ抑制凝块收缩的机制可能是由于直接抑制了Ｃａ２＋内流所致。
Berberine against platelet-rich plasma clot contraction was studied, the results show that ① berberine (BR) concentration of 0.29 ~ 0.87mmol · L-1. There is a very significant inhibition of clot contraction. ②BR concentration of 0.5 ~ 2.0mmol · L-1. No effect on platelet cAMP levels. Tip BR inhibition of clot contraction has nothing to do with cAMP. ③ When the Ca2 + concentration increased from 0 to 11.47mmol · L, the clot shrinkage increased with the increase of Ca2 + influx. Under the same conditions. BR concentration from 0 to 0.6mmol · L-1. The clot shrinkage decreased significantly or very significantly. This suggests that the mechanism of BR inhibition of clotting may be due to direct inhibition of Ca2 + influx.