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目的:探讨生活方式干预和心理干预对新诊断代谢综合征患者的干预效果,为代谢综合征及其相关慢性病的科学防治提供依据。方法:采用整群随机对照试验的方法,将183例新诊断代谢综合征患者分为生活方式干预组(92人)、综合干预组(46人)及对照组45人,干预组进行为期1年干预,对照组除慢性病常规管理外未施加其它任何干预,比较干预前后腰围(WC)、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、胆固醇酯(TC)、高密度脂蛋白(HDL-C)、空腹血糖(FPG)等指标的变化。结果:与干预前相比,生活方式干预组干预后WC、BMI、TG水平降低,综合干预组WC、BMI、DBP、TC水平降低,HDL-C水平升高,对照组HDL-C水平降低、FPG水平升高,差异有统计学意义(P<0.01),对照组其余指标干预前后差异无统计学意义(P<0.05);生活方式干预组及综合干预组与对照组比较,调整后WC、BMI和HDL-C水平差异有统计学意义(P<0.05),综合干预组调整后HDL-C高于生活方式干预组(P<0.01)。结论:干预一年后,生活方式干预及综合干预措施均能有效改善新诊断代谢综合征患者的WC、BMI和HDL-C水平,缓解代谢综合征症状,均为有效的干预措施,但综合干预组与生活方式干预组相比,干预效果并未发现明显优势。
Objective: To explore the effects of lifestyle intervention and psychological intervention on newly diagnosed patients with metabolic syndrome, and provide evidence for the prevention and treatment of metabolic syndrome and its related chronic diseases. METHODS: A total of 183 patients with newly diagnosed metabolic syndrome were divided into lifestyle intervention group (n = 92), comprehensive intervention group (n = 46) and control group (n = 45) by cluster randomized controlled trial. Intervention, the control group in addition to routine management of chronic diseases without any other intervention, compared before and after intervention waist circumference (WC), body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), cholesterol ester (TC), high-density lipoprotein (HDL-C), fasting blood glucose (FPG) and other indicators of change. Results: Compared with those before intervention, WC, BMI and TG decreased after intervention in lifestyle intervention group. The levels of WC, BMI, DBP and TC in the intervention group decreased, while the levels of HDL-C and HDL-C decreased in the intervention group, (P <0.01). There was no significant difference in the other indexes before and after the intervention in the control group (P <0.05). Compared with the control group, the lifestyle intervention group and the comprehensive intervention group had no significant difference in the levels of WC, The levels of HDL-C and HDL-C in the intervention group were significantly higher than those in the lifestyle intervention group (P <0.01). Conclusion: After intervention for one year, lifestyle interventions and comprehensive interventions can effectively improve the levels of WC, BMI and HDL-C in patients with newly diagnosed metabolic syndrome and relieve the symptoms of metabolic syndrome, all of which are effective interventions. However, comprehensive intervention Compared with the lifestyle intervention group, the intervention effect did not find obvious advantages.