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在生物医学领域,如果想要把皮肤细胞转化为心肌细胞或脑细胞,在对细胞重编程的过程中,都需要向细胞中添加额外的基因。但这种方法不仅效率和速度达不到理想状态,给细胞添加基因还可能会导致潜在的危险,例如产生肿瘤。科学家也曾尝试通过移植成人心肌细胞或干细胞来治疗受损心脏。但由于成人心脏产生新细胞的能力极其有限,因此效果均不理想:移植细胞很难存活,且干细胞转化效率较低。如今,由美国加利福尼亚大学旧金山分校华人科学家丁胜领导的
In the biomedical arena, if you want to transform skin cells into cardiomyocytes or brain cells, you need to add extra genes to your cells during reprogramming. However, this method not only fails to achieve the desired efficiency and speed, and adding genes to cells may also lead to potential dangers, such as the generation of tumors. Scientists have also tried to treat damaged hearts by transplanting adult cardiomyocytes or stem cells. However, because of the extremely limited ability of adult hearts to produce new cells, the effect is poor: the transplanted cells are difficult to survive and the stem cells are less efficiently transformed. Today, led by Ding Sheng, a Chinese scientist at the University of California, San Francisco, USA