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T淋巴细胞抗原受体(TCR)的α/β或γ/δ异二聚体与CD3形成抗原受体复合物(TCR/CD3),才能识别抗原刺激并传递抗原刺激信号.CD3一般由4种亚基组成,即CD3γ,δ,ε和ζ.在8条多肽链组成的TCR/CD3复合物中,CD3ε是TCR/CD3复合物装配的起始者和抗原刺激信号的传递者.以抗CD3ε的单克隆抗体模拟抗原刺激,可引起胸腺细胞凋亡(apopto-sis),而在成熟的T细胞中,一般会引起细胞激活、增殖或免疫不应性,CD3ε的激活信号是通过CD3ε的胞内功能区 ITAM(immune receptor tyrosine-based activation motif)而传递的.最近的研究表明,抗CD3ε单克隆抗体也可诱导某些肿瘤细胞的凋亡,这种细胞死亡形式称为激活诱导的细胞死亡(activation-induced cell death).但是,到目前为止,对于CD3ε传递凋亡信号的分子机制尚未见报道.
Antigen stimulation and delivery of antigen-stimulating signals can be recognized by the formation of an antigen-receptor complex (TCR / CD3) from the α / β or γ / δ heterodimers of T-lymphocyte antigen receptor (TCR) Subunits, namely CD3γ, δ, ε and ζ. Among the TCR / CD3 complexes consisting of 8 polypeptide chains, CD3ε is the initiator of TCR / CD3 complex assembly and the transmitter of antigen stimulation signal. Of mAbs mimic antigenic stimulation and can cause apopto-sis, whereas in mature T cells, they usually cause cell activation, proliferation or immune inactivity, and the activation signal of CD3 [epsilon] is through CD3 [epsilon] cells Which is transmitted by ITAM (immune receptor tyrosine-based activation motif) .Recent studies have shown that anti-CD3ε monoclonal antibody can also induce apoptosis in some tumor cells, which is called activation-induced cell death (activation-induced cell death) .However, no molecular mechanism has been reported for the transmission of apoptotic signals to CD3ε up to now.