论文部分内容阅读
黑色素瘤相关抗原(melanoma-associated antigen,MAGE)-A基因亚家族在许多肿瘤组织有较高的表达,同时在除睾丸和胎盘外的正常组织均不表达,是肿瘤免疫治疗的重要靶分子。MAGE-A基因的表达受启动子的去甲基化和组蛋白的乙酰基化调控,与恶性肿瘤的临床分期、转移、复发及预后相关,其功能尚不清楚,可能参与调控Ets转录因子、抑癌基因p53及成纤维细胞生长因子受体2基因,与细胞信号转导通路有关。
The melanoma-associated antigen (MAGE) -A gene subfamily is highly expressed in many tumor tissues and is not expressed in normal tissues except testis and placenta. It is an important target of tumor immunotherapy. The expression of MAGE-A gene is regulated by promoter demethylation and histone acetylation, which is related to the clinical stage, metastasis, recurrence and prognosis of malignant tumor. The function of MAGE-A gene is unclear and may be involved in the regulation of Ets transcription factor, Tumor suppressor gene p53 and fibroblast growth factor receptor 2 genes, and cell signal transduction pathway.