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目的探讨轻、重手足口病患儿血清前白蛋白(PA)及免疫球蛋白水平的变化及临床价值。方法检测1 052例轻、重不同的手足口病患儿的血清PA及免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)水平,比较其在轻、重病例中的变化。按病情程度分为普通组612例,重症组440例,对PA及IgG、IgM、IgA水平及检测结果进行回顾性分析。结果重症病例组PA及IgG水平明显低于普通病例组,差异均有统计学意义(P<0.05)。结论手足口病患儿病情的危重程度与PA及IgG水平有一定的相关性,病情越重,PA及IgG水平呈越低。因此,血清前白蛋白和免疫球蛋白的检测可对手足口病的病情变化及预后评估有重要的参考价值。
Objective To investigate the changes and clinical value of serum prealbumin (PA) and immunoglobulin levels in children with light and heavy hand-foot-mouth disease. Methods Serum levels of PA and IgG, IgM and IgA in 1 052 children with HFMD were detected. The levels of serum PA, Changes in the case. According to the severity of the disease, 612 patients were divided into general group and 440 severe patients. The levels of PA, IgG, IgM, IgA and the detection results were analyzed retrospectively. Results The levels of PA and IgG in severe cases were significantly lower than those in normal cases (P <0.05). Conclusions The severity of HFMD in children with hand-foot-and-mouth disease is correlated with PA and IgG levels. The more severe the disease, the lower the PA and IgG levels. Therefore, the detection of serum prealbumin and immunoglobulin may have important reference value for the changes of hand foot and mouth disease and prognosis.