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目的:究血浆热休克蛋白-60(HSP60)与肿瘤特异性生长因子(TSGF)联合检测对甲状腺癌的早期诊断价值。方法:于2011年1月~2015年11月期间选取254例甲状腺癌患者(定为甲状腺癌组)、156例结节性甲状腺肿患者(结节性甲状腺肿组)和202例健康者(健康组)为研究对象,采用ELISA法检测三组血浆HSP60、TSGF水平,分析其与甲状腺癌病理因素的关系及诊断的敏感度和特异度。结果:甲状腺癌组的血浆HSP60、TSGF水平均显著高于结节性甲状腺肿组以及健康组,且结节性甲状腺肿组高于健康组,差异均具有统计学意义(P<0.05)。甲状腺癌患者血浆HSP60、TSGF水平与年龄、性别、临床分期均无相关性(P>0.05)。血浆HSP60、TSGF单独诊断甲状腺癌的敏感度和特异度分别为68.75%、81.82%和83.33%、71.88%,两者联合诊断的敏感度和特异度则分别达到了88.89%和86.72%。结论:在甲状腺癌的早期诊断中,采用血浆HSP60和TSGF联合检测的方式可靠性较高,值得推广应用。
Objective: To investigate the value of combined detection of plasma heat shock protein-60 (HSP60) and tumor-specific growth factor (TSGF) in the early diagnosis of thyroid cancer. Methods: From January 2011 to November 2015, 254 patients with thyroid cancer (defined as thyroid cancer), 156 patients with nodular goiter (nodular goiter) and 202 healthy subjects (healthy Group) as the research object, the levels of plasma HSP60 and TSGF in three groups were detected by ELISA, the relationship between them and the pathological factors of thyroid carcinoma and the sensitivity and specificity of diagnosis were analyzed. Results: The plasma levels of HSP60 and TSGF in thyroid cancer group were significantly higher than those in nodular goiter group and healthy group, and those in nodular goiter group were higher than those in healthy group (P <0.05). Thyroid cancer patients with plasma HSP60, TSGF levels and age, gender, clinical stage were not related (P> 0.05). The sensitivity and specificity of plasma HSP60 and TSGF in the diagnosis of thyroid cancer alone were 68.75%, 81.82% and 83.33%, 71.88% respectively. The sensitivity and specificity of combined diagnosis of the two were 88.89% and 86.72% respectively. Conclusion: In the early diagnosis of thyroid cancer, the combined detection of plasma HSP60 and TSGF has high reliability and is worth popularizing.