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本文研究噻芬太尼的镇痛药效和制动作用,评价其致身体依赖性潜力。小鼠热板法测得噻芬太尼的镇痛作用强度分别为吗啡、芬太尼和埃托啡的3260,22和1.5倍。以瘫痪作为制动指标测得噻芬太尼对大鼠、家兔、狗和猴制动作用强度为埃托啡的2～3倍。小鼠跳跃实验和大鼠饮药液自然戒断实验表明该药具有一定致身体依赖性潜力。大鼠ⅳ快速成瘾实验及长达20周的猴身体依赖性实验则未出现依赖性戒断症状。
This article studies the analgesic efficacy and brakes of thio-fentanyl and evaluates its potential for body-dependence. The intensity of the analgesic effect of thiophene in mice was 3260, 22 and 1.5 times that of morphine, fentanyl and etorphine, respectively. To paralysis as a braking index measured by thiophene in rats, rabbits, dogs and monkeys braking force intensity of 2 to 3 times that of etorphine. The mice jumping experiment and the natural withdrawal test in rats showed that the medicine has certain potential for body dependence. There was no dependence-dependent withdrawal symptoms in rats after rapid addiction and in monkey body-dependent up to 20 weeks.