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目的观察阿奇霉素与左氧氟沙星联用在治疗军团菌肺炎的临床疗效和不良反应。方法将72例社区获得性军团菌肺炎病人随机分为为观察组和对照组各36例,观察组采用阿奇霉素0.25g+250ml生理盐水静滴,1次/d,对照组采用红霉素1.0g+500ml5%葡萄糖液静滴,1次/d,2组均再加用左氧氟沙星0.5g,1次/d静滴,共用药2周。结果 2组总有效率分别为91.7%和88.9%,差异没有统计学意义(p>0.05);2组胃肠道反应分别为11.1%和52.8%,差异有统计学意义(p<0.01)。结论阿奇霉素联用左氧氟沙星治疗军团菌肺炎疗效好,副作用少。
Objective To observe the clinical efficacy and side effects of azithromycin and levofloxacin in the treatment of Legionella pneumonia. Methods 72 cases of community-acquired Legionnaires pneumonia were randomly divided into observation group and control group, 36 cases in each group. The observation group was treated with azithromycin 0.25g + 250ml saline once a day, while the control group received erythromycin 1.0g + 500ml5% glucose solution intravenous infusion, 1 / d, 2 groups were levofloxacin 0.5g, 1 / d intravenous infusion, a total of 2 weeks. Results The total effective rates of the two groups were 91.7% and 88.9%, respectively, with no significant difference (p> 0.05). The gastrointestinal reactions in the two groups were 11.1% and 52.8%, respectively, with statistical significance (p <0.01). Conclusion Azithromycin combined with levofloxacin in the treatment of Legionella pneumonia is effective and has few side effects.