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目的:探讨益气化瘀方对急诊经皮冠状动脉介入治疗(PCI)急性心肌梗死(AMI)术后患者氧化应激和炎症反应的影响。方法:选取急诊PCI术后的AMI患者100例,随机分为2组各50例,2组均给予常规西医治疗,治疗组在西医基础上予口服益气化瘀方汤剂。于治疗前后测定血清过氧化物歧化酶(SOD),丙二醛(MDA)及高敏C-反应蛋白(hs-CRP)的水平。结果:总有效率治疗组为94.0%,对照组为90.0%,2组比较,差异无统计学意义(P>0.05)。显效率治疗组为74.0%,对照组为62.0%,2组比较,差异有统计学意义(P<0.05)。治疗后1、2、4周,2组MDA、SOD水平均较治疗前升高,hs-CRP水平降低,差异均有统计学意义(P<0.05);且治疗2、4周时治疗组上指标改善较对照组更显著(P<0.05)。结论:益气化瘀汤能显著提高PCI术后患者血清SOD、MDA水平,降低hs-CRP水平,临床疗效肯定。
Objective: To investigate the effects of Yiqi Huayu Recipe on oxidative stress and inflammation in patients with acute myocardial infarction (AMI) after emergency percutaneous coronary intervention (PCI). Methods: One hundred patients with acute myocardial infarction (AMI) after PCI were randomly divided into two groups (n = 50 in each group). The two groups were given conventional western medicine. The treatment group was given Yiqi Huayu decoction on the basis of western medicine. Serum levels of superoxide dismutase (SOD), malondialdehyde (MDA) and high-sensitivity C-reactive protein (hs-CRP) were measured before and after treatment. Results: The total effective rate was 94.0% in the treatment group and 90.0% in the control group. There was no significant difference between the two groups (P> 0.05). The markedly effective rate was 74.0% in the treatment group and 62.0% in the control group. There was significant difference between the two groups (P <0.05). At 1, 2 and 4 weeks after treatment, the levels of MDA and SOD in both groups were significantly higher than those before treatment and the levels of hs-CRP were lower in the two groups (P <0.05) The index improvement was more significant than the control group (P <0.05). Conclusion: Yiqi Huayu Decoction can significantly increase serum SOD and MDA levels and reduce hs-CRP level after PCI, and the clinical curative effect is definite.