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T-2毒素是一种由某些真菌产生的剧毒化合物,对于不同的实验动物以及不同的给药途径,其LD_(50)为0.5～5 mg/kg。在实验研究中,作者发现大部分T-2毒素中毒的实验动物是死于中毒性肺水肿以及肠功能紊乱所致体液大量丢失。因此,作者考虑是否能用皮质类固醇类药物来对抗T-2毒素的毒作用。选用雄性Sprague Dawley大鼠作实验,体重220～290g。经过4～5天适应期后,随机分组。实验在上午8～9时进行。T-2毒素溶解在乙醇:生理
T-2 toxin is a highly toxic compound produced by certain fungi. Its LD50 is 0.5-5 mg / kg for different experimental animals and different routes of administration. In experimental studies, the authors found that most of the T-2 toxin poisoning laboratory animals died of toxic pulmonary edema and significant loss of fluid from bowel disorders. Therefore, the authors consider whether corticosteroids can be used to counteract the toxic effects of T-2 toxins. Selected male Sprague Dawley rats for experiment, weighing 220 ~ 290g. After 4 to 5 days after the adaptation period, randomized. The experiment was carried out at 8 am to 9 am T-2 toxin dissolved in ethanol: Physiology