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目的 探讨幽门螺杆菌感染对MG7抗原动态表达的影响及意义。方法 采用免疫组化技术、PCR方法及ELISA方法 ,对 2 91例胃黏膜的MG7抗原表达情况及幽门螺杆菌感染情况进行检测 ,并对 34例幽门螺杆菌相关性胃疾病患者进行随访。结果 肠上皮化生、异型增生与萎缩性胃炎中 ,幽门螺杆菌感染阳性组和阴性组的MG7抗原阳性表达率接近。浅表性胃炎中幽门螺杆菌阳性组MG7抗原阳性表达率显著高于阴性组 (P <0 .0 5 )。随访发现 3例幽门螺杆菌阴性的病例中 ,1例变为阳性 ,并且MG7抗原表达亦相应变强 ;在 31例幽门螺杆菌阳性的病例中 ,3例MG7抗原阳性者转变为早期胃癌 ,其中 1例MG7抗原表达为强阳性者 ,经手术及化疗后 ,幽门螺杆菌转阴 ,MG7抗原表达亦转为弱阳性。结论 幽门螺杆菌感染与MG7抗原阳性表达有一定的相关性。幽门螺杆菌阳性的MG7抗原阳性表达病例 ,具有较高恶变倾向
Objective To investigate the effect of Helicobacter pylori infection on the dynamic expression of MG7 antigen and its significance. Methods Immunohistochemistry, PCR and ELISA were used to detect the expression of MG7 antigen in 2191 gastric mucosa and the infection of Helicobacter pylori. 34 patients with Helicobacter pylori associated gastric diseases were followed up. Results In intestinal metaplasia, dysplasia and atrophic gastritis, the positive expression rate of MG7 antigen in Helicobacter pylori positive group and negative group was close. The positive expression rate of MG7 antigen in Helicobacter pylori positive group in superficial gastritis was significantly higher than that in negative group (P <0.05). Follow-up found that 3 cases of H. pylori-negative cases, 1 case became positive, and MG7 antigen expression correspondingly stronger; in 31 cases of Helicobacter pylori-positive, 3 cases of MG7 antigen positive transformed into early gastric cancer, which One case of MG7 antigen expressed strongly positive, after surgery and chemotherapy, Helicobacter pylori negative, MG7 antigen expression also turned weak positive. Conclusion Helicobacter pylori infection has positive correlation with the positive expression of MG7 antigen. Helicobacter pylori-positive MG7 antigen positive expression of cases, with a high tendency to malignant